Lincoln City reached the fifth round of the FA Cup for the first time in their history, after they came from behind to beat Brighton & Hove Albion 3-1 on Saturday.
The non-league club fell behind in the first half against Championship high-flyers Brighton, before three second-half goals ensured an historic result at Sincil Bank.
The visitors took the lead in the 24th minute with a goal from Richie Towell, before the game was turned on its head in the second half.
Alan Power equalised for the National League leaders from the penalty spot, before a Fikayo Tomori own goal gave Lincoln a shock lead.
Theo Robinson, who scored twice against Ipswich in the previous round, completed the giant-killing in the 85th minute.
One of the biggest shocks of the day came at Anfield where Liverpool fell to a disappointing 2-1 defeat to Championship strugglers Wolves.
Wolves took the lead in the first minute when Richard Stearman headed past Loris Karius from a free-kick.
The Championship club doubled their lead on the stroke of half-time after Andreas Weimann took the ball around Karius to score.
Divock Origi halved the deficit in the 85th minute with a tap in from close range, but it was too little too late, as Jurgen Klopp’s men suffered their second cup exit in three days.
Tottenham left it late to overcome a stubborn Wycombe side, as they survived falling behind twice to win an eventful encounter 4-3.
Wycombe took a surprise 2-0 lead into the interval courtesy of goals from captain Paul Hayes, the first a smart volley and the second from the penalty spot.
Spurs fought back to equalise through Son Heung-Min and a Vincent Janssen penalty, before Wycombe looked to have won the tie when 36-year-old substitute Garry Thompson struck in the 83rd minute.
However, Dele Alli levelled in the 89th minute, before Son scored his second in the seventh minute of added time to break Wycombe’s hearts.
League One Oxford scored three times in the second-half to eliminate Championship leaders Newcastle United. After a goalless first half, Kane Hemmings, Curtis Nelson and Toni Martinez secured Oxford’s passage to the fifth round for the first time in 23 years.
Theo Walcott bagged a hat-trick as Arsenal hammered Southampton 5-0. Danny Welbeck also scored twice on his long-awaited return from injury.
Crystal Palace joined fellow Premier League side Southampton in departing the competition, as they suffered a 3-0 reverse at home to Manchester City.
Chelsea made light work of Championship side Brentford as they cruised to a 4-0 victory, with Michy Batshuayi scoring twice.
Wes Morgan’s late header salvaged a draw for Premier League champions Leicester, as they drew 2-2 with Derby. The Championship club had fought back from a goal down to lead before Morgan’s goal forced a replay.
Elsewhere, Sean Dyche’s Burnley beat out-of-form Bristol City 2-0, while Rochdale lost 4-0 at home to Huddersfield.
Blackburn scored twice to see off League Two Blackpool, while there was no shock to be had on Teesside, as Middlesbrough won 1-0 at home to Accrington.